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If you normally absorb 20% of your oral dose and then one day absorb 40% (perhaps due to oral pH changes, a small cut under the tongue, or a different holding technique), you effectively received double your usual dose

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A one-week acclimatization period was observed prior to the commencement of experiments to allow the animals to adjust to the laboratory conditions

doi: 10.1007/s00395-013-0330-8 136 KhalidNPatelPDAlghareebRHussainAMaheshwariMV