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A 2018 randomized clinical trial found that a good vocal hygiene program can resolve benign vocal fold nodules without surgery (Hoyosa et al.) In fact, the most benign lesions in the study resolved without additional voice therapy, much less surgery

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However, this difference was not statistically significant

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FASEB Journal 27, 13941403.CrossRefGoogle ScholarPubMed Sandalova, T et al

In metabolic tissues, such as adipose tissue, increased ROS levels have been associated with the carbonylation of key mitochondrial proteins, including the phosphate carrier protein and NADH dehydrogenase (83)