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When stress increases cortisol, it has the ability to blunt GnRH pulses, but peptide signals can restore pulse frequency and amplitude, which supports appropriate FSH and LH release

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Although the interaction between these compounds has not been classified as synergistic, it is relatively strong and after the verification by different types of tests or in vivo studies (Vitale et al., 2005) it might change character, as it was observed previously in the case of caspofungin/amphotericin B combination used against C

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The development of airway remodeling may not be solely due to local airway inflammation