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Kimura Y, Matsumoto M, Den YB, Iwai K, Munehira J, Hattori H, Hoshino T, Yamada K, Kawanishi K, Tsuchiya H

doi: 10.1016/j.fsi.2010.01.012

Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability

Anti-cancer drugs such as PTX can exacerbate this effect by inhibiting microtubule dynamics, which are critical for mitochondrial transport and distribution within cells

Edaravone-dexborneol (EDB) is a clinically validated neuroprotective drug for acute ischemic stroke, yet the precise pathways underlying its therapeutic effects remain unclear

In the last few years, various GSH modulation-enhanced combinational therapy strategies have been extensively exploited, accompanied by the development of versatile metal-based nanosystems with different structures, functionalities, and treatment performances ( In view of the rapid development of GSH-responsive and -exhausting metal nanomedicines in potentiating cancer therapy, we summarize and outline the recent advancements, mechanisms, prospects, and challenges in this field from different strategies (Scheme 1)