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We also confirmed that 6 h of ML226 treatment in HeLa cells impaired OGDHc activity using a colorimetric assay (Fig

Therefore, in-depth exploration of the interactions between these signaling pathways could help develop combined therapeutic strategies targeting both ferroptosis and cuproptosis

By introducing more omega-3 fatty acids, vitamin D, and antioxidants to the dietary regime and, at the same time, making the necessary macronutrient changes like the reduction of the intake of saturated fats and carbohydrates, successful management of symptoms and metabolic health improvement is expected