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In numerous epimutants (UR2, UR8 to UR30), a heterochromatin island impinges on the promoter region of the essential cup1 + gene (Torres-Garcia et al, 2020b), which encodes a mitochondrial LYR protein predicted to be an assembly factor for mitochondrial electron transport chain (ETC) complexes (Angerer, 2015)

It's also worth noting that vitamin C acts as an enzymatic cofactor in the hydroxylation of proline and lysine, a crucial step in collagen synthesis

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Enzyme pattern of biliary colic: A counterintuitive picture

To further substantiate the findings, molecular and cellular studies need to be conducted to examine the regulatory effect of combined EGCG and curcumin on oxidative biomarkers in aging-induced learning impairment