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Osteopontin gene deletion reduces renal expression of dynamin-3 and LDL receptor and lowers blood pressure in Alport syndrome mice 144

Additionally, patients with poorly managed diabetes, severe renal impairment requiring dialysis, or ongoing substance abuse issues must undergo necessary optimization measures before consideration

Proteoglycans are major ECM constituents, and their loss accompanies irreversible cartilage degeneration (Wei et al., 2021)

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