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doi: 10.1172/JCI135536 94 BerthierCCZhangHSchinMHengerANelsonRGYeeBet al

M1 and M2 macrophage phenotypes A classification system in which heterogeneous macrophages are grouped as either M1, which defines activated pro-inflammatory macrophages associated with protection against bacteria and viruses, and M2, which are alternatively activated macrophages that express different markers and are associated with wound healing and immune suppression

It works by inhibiting the activity of tyrosinase, the enzyme responsible for melanin production

Perhaps theres more to these shifts than meets the eye

1 2 3 "Uniting sex and eukaryote origins in an emerging oxygenic world"

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