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Immune checkpoint inhibitors (ICIs) have dramatically improved survival in a subset of patients by reactivating exhausted T cells [1]

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The domain structure includes the N-terminal region that comprises LCD, a C-terminal domain with an RNA-recognition motif (RRM), several RGG-rich regions, a zinc-finger (ZnF) domain, and a nuclear localization signal (NLS) domain 61,62

Laxatives are commonly used to treat constipation alone [17], and a systematic review indicates that use of laxation in constipation can attenuate abdominal pain [107], possibly by eliminating excessive stool and gases in the colon