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Similar content being viewed by others Introduction The rapid increase in the prevalence of type 2 diabetes mellitus (T2DM) worldwide can be attributed to changes in environmental factors including less physical activity and over-nutrition

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In the middle, a horizontal pathway shows homocysteine being remethylated to methionine in a reaction that requires folate in the form of 5-methylTHF and vitamin B 12

In another study on 59 nave patients with T2DM, alogliptin (12.5 or 25 mg/d for 3 months) showed improved -cell functioning, insulin resistance, decreased total cholesterol, and atherogenic index [59]

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