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In pancreatic cancer cells, oncogenic K-Ras maintains the nucleotide pool via the MAPK-dependent signaling pathway, leading to MYC upregulation, and the use of MEK inhibitors reduces the incorporation of glutamine-derived nitrogen into purine nucleotides 38

Eur J Med Chem 158:853862

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(7) in agitator tank, add the D phase constituent, with the content of continued mixing and homogenize agitator tank