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Dyslipidemia causes an increase in triglycerides and a decrease in high-density lipoprotein (HDL) cholesterol which poses a high risk for cardiovascular disease (41)

Comparative Clinical, Physiological, and Pathophysiological Outcomes of Revascularization Modalities and Intensive Lifestyle Medicine in Atherosclerotic Coronary Artery Disease Abstract Over the past two decades, evidence from randomized controlled trials has reframed the management of stable (chronic) coronary syndromes from a reflexively interventional paradigm toward one in which guideline-directed medical therapy and intensive lifestyle modification are recognized as central management strategies in many patients with stable disease

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The study also reported that the miR-22 inhibition via the use of its anti-sense antagonist enhanced the expression of estrogen receptor 1 and SP1 transcription factor [68]

FIGURE 5 5 Mitochondrial quality control and COPD Mitochondrial quality control is a finely tuned process that encompasses multiple aspects such as mitophagy, mitochondrial dynamics, and mitochondrial biogenesis, with the overarching goal of maintaining the quantity, morphology, and function of mitochondria