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This temporal specificity identifies the PFG stage as the critical window when oxidative stress management is essential for pancreatic fate specification, with important implications for optimizing directed differentiation protocols

It also plays a critical role in maintaining cellular health by directly neutralising free radicals, as well as by maintaining the activity of vitamins C and E

Mutations in the MTHFR gene, such as C677T or A1298C, can reduce enzyme efficiency, leading to elevated homocysteine and disrupted methylation pathways

Ethics declarations Ethics approval and consent to participate The ethics approval of the SUSTAIN CSX trial applies for this nested substudy

Bismuth Subsalicylate (Pepto-Bismol): It helps cut down the rotten egg smell

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