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Surprisingly, one of the inducers of Gcl-c expression is 4-Hydroxynonenal (HNE), the major end product of lipid peroxidation 27,28

From there it reaches the cytosol via VDAC [15,121] or it is dismutated by IMS-located SOD1 to H 2 O 2 , which reaches the cytosol via diffusion or aquaporins [85,122,123,124,125,126]

Mononuclear MDSCs (M-MDSCs) have been shown to be implicated in resisting immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1) and are associated with receptor tyrosine kinase (KIT) signaling in CRC (100)