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10.1038/nrcardio.2016.203 15 BuschK

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The compound is a quinolinium-class structure (5-amino-1-methylquinolinium) developed as a membrane-permeable selective inhibitor of the nicotinamide N-methyltransferase enzyme

In lipid synthesis, fatty acids initially react with glycerol-3-phosphate to produce 1-acylglycerol-3-phosphate (LPA) in a reaction catalyzed by glycerol-3-phosphate acyltransferase (GPAT)