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PMID 15830915

Curr Med Chem 16(11):13251348

Under oxidative stress, with the increase in ROS expression, Nrf2 is dissociated from the complex and translocated into the nucleus to bind to the promoter antioxidant response element (ARE) sequence, promoting the expression of Nrf2-related antioxidant enzymes, such as SOD, CAT, heme oxygenase-1 (HO-1), and GPx (Zhang et al., 2021