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Initial screening primarily focuses on abnormalities in copper metabolism, including serum ceruloplasmin levels and baseline 24-hour urinary copper excretion

Nutrient depletion will result in elevated AMP/ATP ratio and lowered ATP levels

As absorption is reduced, body stores become low and a deficiency occurs Underlying diseases most commonly include: IBD (inflammatory bowel disease) Intestinal cancer (especially small cell lymphoma) Liver disease Pancreatitis and other pancreatic diseases Symptoms of low B12 levels Typically found in middle-aged or older cats that present with: Weight loss Diarrhea Vomiting Anorexia Thickened intestines In humans, B12 deficiency may also be associated with dementia, cardiovascular disease, and a certain type of anemia, although these are not specifically recognized problems in cats

Overexpressed P5CS gene in transgenic soybean and tobacco under drought stress elevate APX transcripts

Megaloblastic anemia is seen in Vit B12 or folate deficiency, pernicious anemia, and transcobalamin II deficiency

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