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Similarly, alcohol consumption has been shown to reduce glutathione levels, leading to a decrease in methylation

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The five most upregulated genes in astrocytes were HMGB1, HSPH1, PTGES3, SLC7A11 and HSPA4L, while the five most downregulated genes were ANGPTL4, ETNPPL, SLC4A4, SLC6A11 and LINC00499 (Fig

Furthermore, this increased bioavailability might be behind the over-production of uremic toxins (4-hydroxyphenyllactic acid, 4-hydroxyphenylpyruvic acid, indole compounds, kynurenic acid) with the involvement of pro-inflammatory gut microbiota, compounds that contribute to boost oxidative stress and inflammation [26]

doi: 10.1016/j.foodchem.2021.131884 38 AliIZahra N ul ARRSharif HMMBhattiHA