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Conjugation with the ligands that specifically interact with the targeted receptors, those on the BBB and neurons (e.g., folate, lactoferrin, transferrin, insulin, and LDL receptors), enhances the BBB penetration, neuron-targeting efficiency (Guo et al., 2020), and also increases drug bioavailability in the CNS (Gopalan et al., 2020

with one objective in mind : helping biopharma make earlier and better-informed decisions. Bram Goorden, CEO, IXICO #Biotech #Pharma #Neuroscience #ClinicalResearch To view or add a comment, sign in What if the real bottleneck in CNS biotech isnt innovation but confidence in the models used to de-risk it

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As a human person, Im not sure