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Cycling Considerations Most protocols recommend cycling off after 12 to 16 weeks to prevent potential receptor desensitization and maintain hormonal sensitivity

Notably, C57BL/6 male mice that received sulforaphane in conjunction with depression-inducing lipopolysaccharide, exhibited lower depressive behaviours on the tail-suspension test and forced swimming test compared to those that did not receive sulforaphane (Zhang et al., 2017)

Interestingly, the crystal structure of the SOCS2Elongin B/C complex revealed that the C-terminus of the SOCS box and the N-terminus of the extended SH2 subdomain (ESS) can interact and maintain the stability of the SH2SOCS box domain interaction (131)