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The development of nanotechnology-based formulations, such as liposomes and nanophytosomes, has shown great promise in enhancing the solubility, stability, and brain bioavailability of these compounds, thereby maximizing their neuroprotective effects in ASD (Moghaddam et al., 2023

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The construction of recombinant adenoviruses expressing a nonspecific RNAi control (shCON) and Peli3 -specific shRNAs (shPeli3 #3 and shPeli3 #4) and the related animal experiments were performed as previously described 47

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