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The experiments show that the problem of Pgp reversal is complex: for example, in cells with 200-fold resistance to vinblastine, verapamil induced twofold decrease of vinblastine resistance, but cross resistance to doxorubicin remained unchanged [36]

As discussed, one of its primary roles is to carry long-chain fatty acids to the mitochondria to be broken down for energy

Q.DongN.WuY.et al (2021)

However, the proliferative characteristics of the TrxR1-deficient mouse cells that have been studied to date disfavor this model (Mandal et al., 2010

Mitochondrial function assay in this study showed that OD 550nm values were remarkably up-regulated from the NC (0.38 0.04), GSH (0.43 0.07), SeNPs (0.59 0.04) groups to the GSH + SeNPs group (0.68 0.05