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Such results imply that metformin could aggravate tau pathology, potentially via the overactivation of AMPK and downstream GSK3, since excessive AMPK activity has been linked to tau aggregation in other models [181]

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Notably, the magnitude of the protective effect of HK-2 orally ingested 10 days after exposure was profoundly lower than that of the preventive treatment [156]

TA Instrument, New Castle, DE, USA) was used for the analysis of DSC data

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Redman, C