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Whether the perturbed activation of the Wnt signaling pathway affects the state of oxidative stress also needs further investigation

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The participation of reactive aldehydes in LDL-receptor interactions was documented by several immunohistochemical analyses of atherosclerotic lesions from human aorta, using antibodies against various aldehyde adducts, such as HNE-histidine (Uchida et al., 1995), N-MDA-lysine (Uchida et al., 1997), and N-acrolein-lysine (FDP-lysine) (Uchida et al., 1998a), in which intense positivities were associated with cells, primarily macrophages