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More help Overall Assessment of the AOP Addressess the relevant biological domain of applicability (i.e., in terms of taxa, sex, life stage, etc.) and Weight of Evidence (WoE) for the overall AOP as a basis to consider appropriate regulatory application (e.g., priority setting, testing strategies or risk assessment)

rotundifolia fruits inhibited the proliferation of human CRC cells through down-regulating Cyclin D1 and cyclin-dependent kinases-4 (CDK4) (Yan et al., 2023)

These findings align with recent evidence that modulation of BBB transport mechanisms can rapidly enhance A removal and improve functional outcomes in AD models 25

HK-2 cells were treated with 600 M MG for 24 h, with three replicates per treatment group

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