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It was first identified in the early 1970s by Dr

Int J Mol Sci 2019 20:3598

The expression of HvGR1 was mainly localized to shoot tissues and only slight expression was observed in roots

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Glutamate/aspartate transporter (GLAST), taurine transporter and metallothionein mRNA levels are differentially altered in astrocytes exposed to manganese chloride, manganese phosphate or manganese sulfate

Consequently, deficiencies in any of these processes caused by the loss of ATM could be used as therapeutic targets.1110 Consistent with this notion, ATM-null CLL cells are defective in homologous recombination repair (HRR), a deficiency that can be exploited to induce tumor-specific killing via enhanced requirement for HRR upon PARP-inhibition.11 ATM is also implicated in redox homeostasis.12 Deregulation of redox homeostasis results in oxidative stress and occurs either due to increased reactive oxygen species (ROS) production or reduced antioxidant capacity