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It refers to the heritable changes in gene expression that are not caused by alterations in DNA sequence, including DNA methylation, RNA methylation, chromatin remodeling, and non-coding RNA, and has attracted tremendous research interest owing to its critical role in biological processes such as gene expression, protein function, biological senescence, and disease development ( Most of our knowledge about epigenetics comes from cancer research, but recently, there has been a marked increase in interest in cardiovascular epigenetics ( In recent years, natural products have been widely used to prevent and treat a variety of diseases due to their good safety profile and high application value

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Unfortunately, however, there are no FDA-approved drugs for the treatment of noise-related hearing loss, meaning that there are no specific therapeutic targets or effective drug delivery strategies