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Description

As the damage to the membrane structure and organelles increases, a new wave of ROS and inflammatory factors further feedback into the pathways of ferroptosis and necroptosis, amplifying their effects

Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment

Mitchell KG, Ikoma N, Nelson DB, Maru DM, Erasmus JJ, Weston BR, Vaporciyan AA, Antonoff MB , Mehran RJ, Rice DC, Roth JA, Swisher SG, Sepesi B, Walsh GL, Correa AM, Das P, Blum MA, Badgwell BD, Hofstetter WL

Reference: 18.4ea71002.1784956993.5f327053

10.1186/s13024-019-0349-x 112 Parkinson Study Group (1989)

And a recent research shown that DNA polymerase gamma deficiency induced mtROS increasing which promotes RICTOR expression to trigger pro-survival autophagy [74]