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Despite these considerations, our study does not establish a causal relationship between elevated brain MMA and PPI impairment, nor does it confirm that the rescue of PPI impairment by vitamin B12 is due to reduced MMA levels

10.1016/j.jmb.2015.03.015 193 VandebrielR

If hydrostatic pressure in the kidneys drops too low, as can happen in dehydration, the functions of the kidneys will be impaired, and less nitrogenous wastes will be removed from the bloodstream

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