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Nuclear receptor cofactor 4 (NCOA4) is a selective cargo receptor for ferritin phagocytosis, i.e., catabolism of ferritin by autophagy, and overexpression of NCOA4 increases ferritin catabolism and promotes ferroptosis (37)

Glutathione Mode of Action: The mode of action of Gluthin revolves around the intriguing world of melanin, the pigment responsible for skin color Melanin production is influenced by precursors like L-Phenylalanine, L-tyrosine, and LDOPA The enzyme tyrosinase plays a pivotal role in converting LDOPA to the reactive intermediate opaque none, which then leads to melanin formation Gluthione competitively inhibits melanin synthesis by interrupting the binding of LDOPA