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Upon mPTP opening, cytochrome c (Cyt c) is released from the mitochondrial intermembrane space into the cytosol, initiating the intrinsic (mitochondrial) apoptotic pathway

Furthermore, propionic acid stimulates enteric neurons to release glutamate, which activates vagal afferents to transmit signals to the CNS, modulating mood-related brain circuits ( Foundation for SCFA production: dietary fiber (especially fructans and galactooligosaccharides) can significantly increase the abundance of Bifidobacterium and Lactobacillus in the gut (124), and these two bacterial groups are the main producers of SCFAs (100102)

Peer review Peer review information Nature Medicine thanks Melanie Chan and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

Faster Processing: Speed is one of the greatest benefits of magnetic bead protein purification

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