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[DOI] [PMC free article] [PubMed] [Google Scholar] Jerome MS, Kuthethur R, Kabekkodu SP, Chakrabarty S

Superoxide measurements in liver and kidney by electron paramagnetic resonance (EPR) spectroscopy Mitochondrial superoxide in liver and kidney tissue was measured by EPR spectroscopy using a mitochondrial targeted probe, 1-hydroxy-4-[2-triphenylphosphonio)-acetamido]-2,2,6,6-tetramethylpiperidine,1-Hydroxy-2,2,6,6-tetramethyl-4-[2-(triphenylphosphonio)acetamido] piperidinium dichloride (mito-TEMPO-H) (Enzo Life Sciences, Farmingdale, NY) 24,25

doi: 10.1038/clpt.2014.174 196

Several mechanisms contribute to therapy resistance such as xenobiotic-metabolism, drug efflux, and apoptosis evasion, among several others [6]

The response to levodopa in Parkinsons disease: imposing pharmacological law and order

Moreover, Con A-injected mice also showed low GSH/GSSG ratio, increased hydrogen peroxide and high MDA level in the liver and spleen compared with Con A-injected WT mice (Figure 6)