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In PtGSTU19Y160F variant, the apparent affinity for glutathione was reduced by a factor 4 with PITC as electrophilic substrate while no variation was detected with BITC

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Wang M , Rule S, Martin P, Goy A, Auer R, Kahl BS, Jurczak W, Advani RH, Romaguera JE, Williams ME, Barrientos JC, Chmielowska E, Radford J, Stilgenbauer S, Dreyling M, Jedrzejczak WW, Johnson P, Spurgeon SE, Li L, Zhang L, Newberry K, Ou Z, Cheng N, Fang B, McGreivy J, Clow F, Buggy JJ, Chang BY, Beaupre DM, Kunkel LA, Blum KA

These haptenated HLA-B*57:01 bound peptides were displayed (i) through antigen processing of flucloxacillin-modified intracellular proteins, and (ii) direct binding of flucloxacillin to peptides already displayed by B*57:01 on the surface of antigen presenting cells

Amsterdam, the Netherlands: Elsevier

This is because contemporary formulations and skin physiology allow both ingredients to retain their activity and deliver complementary benefits when layered correctly, reinforcing that thoughtful ingredient pairing is more important than outdated interaction myths