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Wu S, Wang Q, Du J, Zhu L, Yang F, Lu J, Li X, Li Y, Cui J, Miao Y

Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells

These experiments showed that NAPQI-induced cell death was reduced by increased GPx3 expression and was enhanced by decreased GPx3 expression, suggesting a crucial role for intracellular GPx in preventing the oxidative stress induced by NAPQI

Notably, the ROS-induced NFkB response is multi-faceted since it can activate the expression of both antioxidant proteins, including MnSOD, Cu/ZnSOD, CAT 52 , 54 - 57

The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma

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