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Route changes the pharmacodynamic profile, not just the amount absorbed

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Heffernan 2001a Mouse studies using chronic osmotic pump delivery showed AOD-9604 increased fat oxidation and plasma glycerol (a lipolysis marker) to a degree comparable with full-length hGH, without inducing hyperglycaemia or reducing insulin secretion

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400 The underlying neuroprotective mechanisms involve increased levels of miR-21, miR-27a, and miR-146a, along with decreased expression of target proteins

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