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Screening of overlap genes and functional annotation In this study, the R package limma was used to calculate the fold change value of gene expression level to uncover the overlapping genes of various SAAM groups

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IGF-1 LR3 is recommended to patients with the following conditions: hormone deficiency in children that results in short stature, adult growth deficiency, short bowel syndrome, short stature due to Turner Syndrome, adult deficiency associated with pituitary tumors or treatment of these tumors and muscle-wasting disease related to HIV/AIDS [10]

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However, unfortunately, although in vitro and in vivo experiments have clarified Fer-1s protective effect on the DR retina and its ferroptosis-regulating mechanism, corroborating the clinical potential of ferroptosis-targeted intervention, critical limitations remain in its targeting specificity, potential off-target risks and clinical translational potential of preclinical models