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New England Journal of Medicine 347:1025-1026, 2002

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Two lipid metabolism-associated genes, acyl-CoA synthetase long-chain family member 4 (ACSL4) and lysophosphatidylcholine acyltransferase 3 (LPCAT3), encode enzymes required for the acylation and insertion of PUFAs into membrane phospholipids, respectively (24,50)

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Previous reports have shown T-cell-mediated cytotoxicity is highly sensitive to even small changes on the immune synapse formation by bispecific T-cell engagers 34,35 and it is likely that albumin could cause interference in the efficiency of immune synapse formation or signalling 32 , although its potential impact on the functionality of binding domains also cannot be ruled out