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Cancer 14(10):2283-8, 2008

doi: 10.3389/fnsys.2025.1502589 Received 27 September 2024 Accepted 28 February 2025 Published 21 March 2025 Volume 19 - 2025 Edited by Marco Cavagli, Polytechnic University of Turin, Italy Reviewed by Richard H

acidophilus produces SCFAs like acetate, which activate Intercellular adhesion molecule-3-Grabbing Non-integrin Receptor 3 (SIGNR3) receptor on dendritic cells, suppressing IL-6/STAT3 and RORt pathways to inhibit Th17 differentiation while promoting Treg expansion, helping restore immune balance ( L.plantarum and A.muciniphila secrete metabolites that bind TLR2, downregulating NF-B to block the IL-23/Th17 axis, Additionally, A

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This is true for healthy individuals and as well as for the elderly or chronically ill who may suffer from persistent low glutathione due to an impaired enzyme that is the first step responsible for making glutathione inside our cells

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