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Overall, 70% of gene promotors are contained within CpG islands including those of housekeeping genes

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FIGURE 1 Together, these elementsmechanism-based classification, PK/PD and biomarker emphasis, explicit clinical and immunotherapy safety benchmarking, multi-omics-enabled translational pipeline, and One Health integrationdifferentiate this article from prior OSC reviews and provide a roadmap from mechanistic promise to clinically and ecologically responsible dual-action application

Single-cell transcriptome analyses reveal endothelial cell heterogeneity in tumors and changes following antiangiogenic treatment

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