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PMID: 38942026 Cancer Cell KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

High MBGS also overlapped with Hoshida S3, Boyault G5/G6, and Chiang CTNNB1 subclass tumors in TCGA and in HCC spatial transcriptomic datasets visually depicting these tumors to be situated in an immunologically cold tumor microenvironment

and/or from about 90% to about 100%

However, unlike pro-fibrotic agents, GHK-Cu also upregulates the activity of matrix metalloproteinases (MMPs) and their inhibitors (TIMPs), facilitating the breakdown of scarred or disorganized collagen