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Description

Mikelsaar M, Zilmer M

Of the four known SDH assembly factors, only mutations in SDHAF1 have been linked to complex II deficiency

Among the mechanisms are a decrease in oxidative stress impairment, and modulation of protein levels linked with the mitochondrial apoptotic pathway and its inhibition

This design was intended to specifically evaluate the protective effect of ALA against CSD-induced oxidative and inflammatory injury, rather than its potential role during recovery