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Importantly, participants in the medications studies will be treated for 12 months and studied at the end of active treatment and again after a 3 month medication washout period to determine whether improvements in beta cell function can be maintained when the active intervention is no longer in place

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Hence, further investigation should focus on the effectiveness and safety profiles of divertin and AMPK activators in human subjects for potential future use

TG, JY, YW, SZ, and YL wrote the manuscript and made the figures

Multiple biomarkers are released by renal cells following AKI, which act as vital measurable indicators to objectively reflect renal physiological and pathophysiological alterations