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Paez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H, Vinals F, Inoue M, Bergers G, Hanahan D, Casanovas O: Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis

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Alternative oral medications include other antibiotics like azithromycin (Zithromax) and minocycline, and the retinoid isotretinoin