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Clin Cosmet Investig Dermatol 7:267274

Carnosic acid, a catechol-type electrophilic compound, protects neurons both in vitro and in vivo through activation of the Keap1/Nrf2 pathway via S-alkylation of targeted cysteines on Keap1

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This was associated with increased survival (Figure 6b) and intra-tumoural GSH levels in combination-treated animals (Figure 6c)

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The reduction in lipogenic gene expression appears attributable to both weight loss and mechanisms independent of weight loss, since a similar magnitude of weight loss induced by a low-calorie diet elicited a smaller reduction in lipogenic gene expression than FGF21 (101)