Foundational Pharmacology & Diet-Induced Obesity Study (Biochemical Pharmacology, 2018) Selective NNMT Inhibition Reverses Diet-Induced Obesity in Mice The foundational published study of 5-Amino-1MQs pharmacological characterisation and in vivo efficacy was published in Biochemical Pharmacology
While oral supplements are available, B12 injections offer better absorption, especially for those with gastrointestinal issues or poor nutrient absorption
(Lee et al., 2005) documented significantly elevated NNMT expression in abdominal subcutaneous adipocytes of obese Pima Indians relative to non-obese counterparts
Gagnon, Catherine
Recommended Injection Sites: Abdomen (2 inches from navel in any direction) Upper thighs (front or outer aspects) Upper arms (if administered by a partner) Rotate injection sites to prevent tissue irritation and lipohypertrophy Injection Supplies: 29-31 gauge insulin syringes (smaller gauge = less discomfort) 0.5-1ml syringe capacity 12.7mm (1/2 inch) needle length Alcohol swabs for site preparation Sharps container for safe needle disposal Injection Procedure: Wash hands thoroughly and prepare injection site with alcohol swab Allow alcohol to dry completely (prevents stinging) Pinch skin gently to create a fold of subcutaneous tissue Insert needle at 45-90 degree angle (depending on body fat thickness) Inject slowly and steadily over 5-10 seconds Withdraw needle and apply gentle pressure if needed Dispose of needle safely in sharps container Reconstitution Instructions 5-Amino-1MQ typically arrives as lyophilized (freeze-dried) powder requiring reconstitution before use
Two-year sustained weight loss and metabolic benefits with controlled-release phentermine/topiramate in obese and overweight adults (SEQUEL): a randomized, placebo-controlled, phase 3 extension study
