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Uricosuric agents like dotinurad enhance UA excretion by targeting specific enzymes involved in purine metabolism

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Inversely, arginase 1 (ARG1) is constantly expressed by anti-inflammatory M2 macrophages

In the hyperglycemic clamping experiment, cotadutide was also found to reduce the de novo fat production of the liver during clamping

Winther KH, Wichman JE, Bonnema SJ, Hegeds L (2017) Insufficient documentation for clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis, based on a systematic review and meta-analysis

In the trioLR analyses, we relied on permutation testing to gage whether signals occurred by chance, and again encourage both replication and biological plausibility as additional milestones for validation