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Large, randomized, placebo-controlled trials have been conducted in both men and women across multiple countries, and the consistent finding is that minoxidil slows or stops hair loss and produces visible regrowth in a large proportion of users

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R 8 is methyl the invention encompasses a cation of Formula IA, wherein: the cation of Formula IA includes two or more non-hydrogen substituents at positions R 2 -R 8 , and wherein: R 5 is H or NH 2 , R 6 is H or F R 7 is H or NH 2 , R 8 is H or methyl