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DZ helped to revise the manuscript and provided important intellectual revision suggestions

Disruption of NADPH production compromises GSH regeneration, limits GPX4-dependent detoxification of lipid peroxides, and can promote ferroptosis even in the absence of impaired GSH synthesis 152

For example, ceruloplasmin is a copper-containing ferroxidase that possesses ferroxidase and antioxidant activity and inhibits iron-and copper-dependent lipid peroxidation and scavenging peroxide and superoxide anions

Certain therapeutic properties mainly anti-inflammatory, wound healing, antioxidant and anti ulcerogenic are mostly attributed to these plant constituents

Liu Y, Yu X, Shen H, Hong Y, Hu G, Niu W, et al