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Furthermore, small-molecule CXCR2 antagonists such as Repertaxin, Navarixin, Danirixin and AZD5069 have also demonstrated potential in reducing neutrophil recruitment in animal disease models (103), showing significant efficacy particularly in sustained inflammatory conditions such as cystic fibrosis, severe asthma and chronic obstructive pulmonary disease (COPD)

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Klein, I., Cornejo, J.C., Polakos, N.K., Beena, J., Wuensch, S.A., Topham, D.J., Pierce, R.H

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