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Its core pathophysiological characteristics are intricately intertwined with abnormal iron and lipid metabolism, oxidative stress, mitochondrial dysfunction, and neuroinflammation, driving the progressive degeneration of dopaminergic neurons in the substantia nigra (SN) ( Figure 2 )

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Leitl M.D., Onvani S., Bowers M.S., Cheng K., Rice K.C., Carlezon Jr W.A., Banks M.L., Negus S.S

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This material is not approved by the U.S